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Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 522-527 doi: 10.1007/s11684-017-0526-7

Abstract: Detecting circulating tumor cell (CTC) or circulating tumor DNA (ctDNA) in plasma or serum could serve as liquidbiopsy, which would be useful for numerous diagnostic applications.Liquid biopsies can help clinicians screen and detect cancer early, stratify patients to the most suitableWe summarized the advantages and disadvantages of tissue and liquid biopsies.In the future, liquid biopsies could be used to guide cancer treatment.

Keywords： liquid biopsy     circulating tumor cells     cell-free ctDNA     exosomes     precision medicine    

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Design and evaluation of a novel biopsy needle with hemostatic function

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 2, doi: 10.1007/s11465-022-0738-7

Abstract: Biopsy is a method commonly used for early cancer diagnosis.However, bleeding complications of widely available biopsy are risky for patients.Safer biopsy will result in a more accurate cancer diagnosis and a decrease in the risk of complicationsIn this article, we propose a novel biopsy needle that can reduce bleeding during biopsy procedures andThe proposed biopsy needle features a compact structure and can be operated easily by left and right

Keywords： cancer diagnosis     biopsy needle     hemostatic function     predictive model     coupled Eulerian−Lagrangian    

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Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 386-392 doi: 10.1007/s11684-017-0574-z

Abstract: In this study, the clinical manifestations of 111 cases of biopsy-proven DN were described, and the clinicalIn conclusion, the clinical characteristics of DN vary, and renal biopsy is necessary to determine renal

Keywords： diabetic nephropathy     clinical characteristics     renal biopsy     outcomes    

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Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis

Riffat Meraj, Kathryn A. Wikenheiser-Brokamp, Lisa R. Young, Sue Byrnes, Francis X. McCormack

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 395-405 doi: 10.1007/s11684-012-0231-5

Abstract: Although surgical lung biopsy is considered the gold standard for obtaining tissue in patients with diffuseThe objective of our study was to examine the utility of transbronchial biopsy in the diagnosis of LAMTransbronchial biopsy specimens were subsequently collected and reviewed by an expert pathologist toWe found that transbronchial biopsy has a yield of approximately 60% in patients with LAM.of LAM, obviating the need for surgical lung biopsy in more than half of LAM patients.

Keywords： lymphangioleiomyomatosis     lymphangiomyomatosis     multicystic lung disease     diffuse cystic lung disease     transbronchial biopsy    

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Novel Non-Protein Biomarkers for Early Detection of Hepatocellular Carcinoma Review

Ghassan K. Abou-Alfa, Lin Wu, Augusto Villanueva

Engineering 2021, Volume 7, Issue 10,   Pages 1369-1374 doi: 10.1016/j.eng.2021.02.020

Abstract:

Early detection of hepatocellular carcinoma (HCC) while in its early stages is critical for reducing HCC mortality in high-risk patients. However, highly sensitive and specific surveillance biomarkers for early-stage HCC detection are still lacking. In recent years, great efforts have been made to research tumor-derived molecular features that are detectable in circulation, such as circulating tumor deoxyribonucleic
acid and circulating tumor ribonucleic acid, in order to explore their potential as non-invasive biomarker candidates in many tumor types. In this review, we summarize current studies on these new approaches and their application in early HCC detection.

Keywords： Hepatocellular carcinoma     Early detection     Biomarkers     Liquid biopsy    

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Chemical probe systems for assessing liquid–liquid mixing efficiencies of reactors

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1323-1335 doi: 10.1007/s11705-022-2275-7

Abstract: Liquid–liquid mixing, including homogeneous and heterogeneous mixing, widely exists in the chemical industry

Keywords： mixing     chemical probe     liquid–liquid     heterogeneous    

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Application progress of lymphography in oncology

Yang YU, Jibin LIU, Lixue YIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 13-19 doi: 10.1007/s11684-009-0016-7

Abstract: Lymphography is often used for the diagnosis of lymphatic metastasis in oncology. Determination of lymphatic metastasis is extremely important for accurate cancer staging, which may directly guide the clinical therapeutic scheme. In recent years, the technology of lymphography has developed rapidly on the basis of traditional lymphography, with the appearance of computed tomography (CT) lymphography, nuclear magnetic resonance (MR) lymphography, contrast-enhanced lymphosonography, and so on; the diagnostic accuracy has also been improved. The imaging principles and methods of these various technologies of lymphography are reviewed in this paper, and their applications and significance in oncology are also discussed in detail.

Keywords： lymphography     lymphatic metastasis     sentinel lymph node biopsy    

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Microfluidic production of liposomes through liquid–liquid phase separation in ternary droplets

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 1017-1022 doi: 10.1007/s11705-021-2118-y

Abstract: make oil-in-water droplets, which can evolve into water-in-oil-in-water double emulsion droplets by liquid–liquid

Keywords： microfluidics     liposomes     ternary droplets     phase separation    

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Energy distribution between liquid hydrogen and liquid oxygen temperatures in a Stirling/pulse tube refrigerator

Frontiers in Energy 2023, Volume 17, Issue 4,   Pages 516-526 doi: 10.1007/s11708-022-0844-6

Abstract: In the present study, an SPR was designed and manufactured to work between the liquid hydrogen and liquid

Keywords： Stirling/pulse tube refrigerator     displacer displacement     space application     phase shift     energy distribution    

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Studies on the liquid-liquid interfacial mass transfer process using holographic interferometry

ZHAO Chaofan, ZHU Chunying, MA Youguang

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 1,   Pages 1-4 doi: 10.1007/s11705-008-0006-3

Abstract: This paper aims at the interfacial phenomena of liquid-liquid mass transfer and its characteristic.It is indicated that the liquid-liquid mass transfer process is approximately in accordance with two-filmtheory, the interfacial performance may be changed by the addition of the solute, and the interface of liquid-liquid

Keywords： liquid-liquid     different     real-time holographic     addition     transfer    

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Perspective on gallium-based room temperature liquid metal batteries

Frontiers in Energy 2022, Volume 16, Issue 1,   Pages 23-48 doi: 10.1007/s11708-022-0815-y

Abstract: Featuring inherent liquidity, metallicity, and biocompatibility, Ga-based room-temperature liquid metalsHerein, to illustrate the glamour of liquid components, high-temperature liquid metal batteries (HTLMBsThen, Ga-based liquid metals as main working electrodes in primary and secondary batteries are reviewedNext, Ga-based liquid metals as auxiliary working electrodes in lithium and nonlithium batteries areThe summary and perspective of Ga-based liquid metals as diverse battery materials are also focused on

Keywords： liquid metals     soft electrodes     flexible batteries     deformable energy supply devices     epidermal electronics    

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Advances and perspectives in catalysts for liquid-phase oxidation of cyclohexane

Hui LI, Yuanbin SHE, Tao WANG

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3,   Pages 356-368 doi: 10.1007/s11705-012-0903-3

Abstract: The latest progress and developments in catalysts for the oxidation of cyclohexane are reviewed. Catalytic systems for the oxidation of cyclohexane including metal supported, metal oxides, molecular sieves, metal substituted polyoxometalates, photocatalysts, organocatalysts, Gif systems, metal-organic catalysts and metalloporphyrins are discussed with a particular emphasis on metalloporphyrin catalytic systems. The advantages and disadvantages of these methods are summarized and analyzed. Finally, the development trends in the oxidation technology of cyclohexane are examined.

Keywords： cyclohexane     liquid-phase oxidation     catalysis    

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Residence time distribution and modeling of the liquid phase in an impinging stream reactor

Xingjun WANG, Xianhui HU, Lishun HU, Guangsuo YU, Fuchen WANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3,   Pages 353-359 doi: 10.1007/s11705-009-0262-x

Abstract: Based on some experimental investigations of liquid phase residence time distribution (RTD) in an impingingstream reactor, a two-dimensional plug-flow dispersion model for predicting the liquid phase RTD inThe axial liquid dispersion coefficient increases monotonously with the increasing liquid flux, but isAs the liquid flux and the gas flux increase, the liquid dispersion coefficient of center-to-wall decreasesthe liquid RTD is dominated mainly by axial liquid dispersion in the impinging stream reactor.

Keywords： RTD     liquid dispersion     reactor     liquid     independent    

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Lifecycle carbon footprint and cost assessment for coal-to-liquid coupled with carbon capture, storage

Frontiers in Energy 2023, Volume 17, Issue 3,   Pages 412-427 doi: 10.1007/s11708-023-0879-3

Abstract: The coal-to-liquid coupled with carbon capture, utilization, and storage technology has the potentialand indirect-coal-to-liquid coupled with the carbon capture utilization and storage technology underand 24%–49% from 7.10 t CO2/t·oil of indirect-coal-to-liquid.Next, the levelized cost of direct-coal-to-liquid is 648–1027 $/t of oil, whereas that of indirect-coal-to-liquidis 285–1364 $/t of oil, compared to 1101–9793 $/t of oil for indirect-coal-to-liquid.

Keywords： coal-to-liquid     carbon capture     utilization and storage (CCUS)     carbon footprint     levelized cost of liquid    

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Review of the direct thermochemical conversion of lignocellulosic biomass for liquid fuels

Jianchun JIANG,Junming XU,Zhanqian SONG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 13-27 doi: 10.15302/J-FASE-2015050

Abstract: Increased demand for liquid transportation fuels, environmental concerns and depletion of petroleum resourcesThermochemical approaches hold great potential for conversion of lignocellulosic biomass into liquidDirect thermochemical processes convert biomass into liquid fuels in one step using heat and catalystsSeveral direct thermochemical processes are employed in the production of liquid biofuels depending ondrop-in liquid fuels may reduce the dependence of the fuel market on petroleum-based fuel products.

Keywords： lignocellulosic biomass     thermochemical     liquid fuels     upgrading     biofuels    

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Title Author Date Type Operation

Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Journal Article

Design and evaluation of a novel biopsy needle with hemostatic function

Journal Article

Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Journal Article

Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis

Riffat Meraj, Kathryn A. Wikenheiser-Brokamp, Lisa R. Young, Sue Byrnes, Francis X. McCormack

Journal Article

Novel Non-Protein Biomarkers for Early Detection of Hepatocellular Carcinoma

Ghassan K. Abou-Alfa, Lin Wu, Augusto Villanueva

Journal Article

Chemical probe systems for assessing liquid–liquid mixing efficiencies of reactors

Journal Article

Application progress of lymphography in oncology

Yang YU, Jibin LIU, Lixue YIN

Journal Article

Microfluidic production of liposomes through liquid–liquid phase separation in ternary droplets

Journal Article

Energy distribution between liquid hydrogen and liquid oxygen temperatures in a Stirling/pulse tube refrigerator

Journal Article

Studies on the liquid-liquid interfacial mass transfer process using holographic interferometry

ZHAO Chaofan, ZHU Chunying, MA Youguang

Journal Article

Perspective on gallium-based room temperature liquid metal batteries

Journal Article

Advances and perspectives in catalysts for liquid-phase oxidation of cyclohexane

Hui LI, Yuanbin SHE, Tao WANG

Journal Article

Residence time distribution and modeling of the liquid phase in an impinging stream reactor

Xingjun WANG, Xianhui HU, Lishun HU, Guangsuo YU, Fuchen WANG,

Journal Article

Lifecycle carbon footprint and cost assessment for coal-to-liquid coupled with carbon capture, storage

Journal Article

Review of the direct thermochemical conversion of lignocellulosic biomass for liquid fuels

Jianchun JIANG,Junming XU,Zhanqian SONG

Journal Article